The Hinkle Lab, ’10-’11:  Chad Anderson, Brett Andrews, Clayton Brittingham, Morgan Ziemba, Kelsey Cone, Blake Forkey, & Karen Hinkle

The research in my laboratory is focused on investigating cellular and molecular alterations resulting from exposure to environmental toxins.  Currently, my students and I are using Saccharomyces cerevisiae as a model system to investigate the effects of exposure to 3-trifluoromethyl-4-nitrophenol (TFM), a pesticide routinely used in the Lake Champlain basin to eradicate the sea lamprey population.  The research is significant for many reasons:  very little is known about the mechanism of action of TMF; moreover, significant non-target species mortality has been frequently noted post TFM treatment, particularly among amphibian species; in addition, this project is of regional significance and may lend insight into the justification for use of TFM in the Lake Champlain basin.